Sara (Cameron Diaz) and Brian (Jason Patric) Fitzgerald's life with their young son (Evan Ellingson) and their two-year-old daughter, Kate (Sofia Vassilieva), is forever altered when they learn that Kate has leukemia. The parents' only hope is to conceive another child, specifically intended to save Kate's life. And what it takes is Anna (Abigail Breslin). Throughout their young lives, the sisters endure various medical procedures and hospital stays—just another part of their close-knit family's otherwise normal life. Until Anna, now 11, says "no." Seeking medical emancipation, she hires her own lawyer (Alec Baldwin), initiating a court case that divides the family and that could leave Kate's rapidly failing body in the hands of fate. Based on the bestselling book from Jodi Picoult, My Sister’s Keeper reveals surprising truths that challenge one's perceptions of family love and loyalty and give new meaning to the definition of healing.