Researchers on the undersea lab Aquatica have genetically altered the brains of captive sharks to develop a cure for Alzheimer's disease. But there's an unexpected side effect: the critters got smarter...and meaner. After a big storm damages their remote research facility, they must fight for their lives as the sharks hunt them down, one by one. All-star cast includes Oscar and Golden Globe-nominee Samuel L. Jackson, Saffron Burrows, LL Cool J, Thomas Jane and Michael Rapaport. Directed by Renny Harlin.